Tools of the Subclavian Trade

Equipment choices for subclavian arterial interventions.

By Michael H. Wholey, MD; Darren Postoak, MD; Raj Suri, MD; Marco Cura, MD; William Wu, MD; and Boulos Toursarkissian, MD
 

The majority of the supra-aortic atherosclerotic occlusive lesions involves the left subclavian artery.1 Such disease results in a “subclavian steal,” which was first described in 1961 by Reivich et al.2 By occluding the left subclavian artery, arterial flow is provided by the right subclavian artery with flow into the right vertebral artery and then retrograde flow into the left vertebral artery, and subsequently into the left subclavian artery (Figure 1). A very common cause of stenotic lesions in these vessels, similar to other vessels, is athereosclerotic disease. However, other causes such as dissection, fibromuscular disease, and various vasculitidies are not infrequent.3

The diagnosis of subclavian steal is based on having upper-extremity ischemia in which a pressure gradient of 20 mm Hg is noted and symptoms of arm claudication, paresis, and atheroembolic digital ischemia are seen. Less commonly, there is vertebrobasilar insufficiency, which includes symptoms of ataxia, diplopia, syncope, vertigo, dizziness, nausea, and vomiting. Another syndrome, which has been increasing in frequency, includes coronary steal syndrome in which a stenosis proximal to internal mammary-coronary artery bypass may cause ischemic symptoms. The more frequent use of the left internal mammary artery (LIMA) for coronary bypass procedures has resulted in greater surveillance and treatment of the left subclavian artery. Although debatable, high-grade, proximal subclavian arterial stenoses in relatively asymptomatic patients is now considered appropriate therapy to maintain the capacity to use the LIMA. Many cases of subclavian artery stenosis or occlusive disease are discovered by CT angiography and MRA, in addition to traditional angiographic means (Figure 2).

Innominate artery stenosis is relatively uncommon. When the atherosclerotic disease involves the innominate artery, the symptoms may be more severe and include cerebral symptoms. The occlusion in the innominate artery causes retrograde flow from the vertebral artery and into the right common carotid and the right subclavian artery. Symptoms generally include vertebrobasilar insufficiency with ataxia, diplopia, syncope, vertigo, dizziness, nausea and/or vomiting. It may also include upper-extremity ischemia and atheroembolic digital ischemia.

ACCESS FOR DIAGNOSING AND TREATING SUBCLAVIAN DISEASE
Your first decision, whether to employ the femoral or brachial arterial approach, will determine which type of sheaths, wires, and stents should be deployed. We generally prefer to come from the common femoral route because of long-term experience and because of the lower risk of hematoma complications that can occur from brachial approaches (Figure 3). We will frequently start with a 5- to 6-F short sheath to perform our diagnostic studies from the femoral access.

The brachial approach is preferred in many subclavian and innominate artery occlusions, especially in lesions lacking a characteristic nipple in the proximal segment of the artery. We will also use this approach when the takeoff of the subclavian or innominate artery is at such a steep angle to the aorta that traditional femoral access is foreboding. Also, if severe aortoiliac disease is present, we will naturally choose the brachial approach (Figure 4).

When selected, we prefer the low brachial approach near the olecranon fossa because of the difficulty in holding pressure to the brachial artery in the upper arm. We will use the micropuncture set system to gain a clean access into the brachial artery and will then place a short 5-F sheath for our initial diagnostic and early intervention. We almost never use the axillary approach because of the brachial plexus injury that can result from an expanding hematoma.

DIAGNOSIS AND INTERVENTION IN THE LEFT SUBCLAVIAN ARTERY
Left Subclavian Stenoses
Once arterial access is obtained, we administer 5,000 units of heparin intravenously. A left anterior oblique projection with the 5-F pigtail catheter in the aortic arch is first performed. Using roadmapping with favorable image angles, we carefully cross the lesion (Figure 5).

Our guidewire selection depends on the lesion characteristic and the sheath/guide catheter that we plan to use. Traditionally, for a moderate stenosis of the left subclavian, a .035-inch Wholey wire (300 cm in length, Malinkrodt, St. Louis, MO) will work well and can be used to provide adequate strength throughout the procedure. The diagnostic catheter used for support is frequently a 5-F, 100-cm-long, hockey stick-shaped catheter. For higher-grade stenoses, we use a .035-inch, regular-angled Glidewire (Terumo, Tokyo, Japan) followed by our diagnostic catheter, which is then exchanged for a metal braided catheter. Equally well-tolerated are the .014-inch support coronary wires (Spartacore, Guidant Corporation, Indianapolis, IN).

With the guidewire past the lesion, we remove the diagnostic catheter and advance the long sheath (6-F to 7-F) or the guide catheter (7-F to 8-F) just proximal to the lesion. If the diagnostic catheter is extra long (125-cm to 135-cm), we can telescope the sheath or guide over the diagnostic catheter and save a step.

We frequently predilate lesions that are severely diseased and that pose a risk of stripping or impeding the passage of our balloon-mounted stents. Predilatation with a 4-mm X 2-cm PTA balloon catheter helps to reduce the risk of stent migration and allows for a quick reference of the vessel size and lesion length.

We recheck the images to see important vessel takeoffs and to assess possible dissections. For ostial lesions, we will occasionally use a right anterior oblique view to see the origin. Generally, a steep left anterior oblique projection works well. Biplane images are very useful, if available. We never advance the sheath over and past the lesion. We then advance the balloon-mounted stent to the lesion, being certain that important vessels such as the internal mammary and the vertebral arteries are not compromised. The balloon-mounted stent is frequently 7 mm to 8 mm in diameter and 15 mm to 20 mm in length. If the vertebral artery is at risk, we leave a .014-inch guidewire as a safety wire in the vertebral artery during subclavian stenting. We then hold the balloon carefully because of the aortic arch pulsations and then deploy the stent quickly to approximately 8 atm. We will then perform angiography after stent placement and assess the stent apposition to the vessel diameter. Unlike other major arteries, the origin of the subclavian artery is somewhat fragile, so we are always cautious not to overdilate this vessel for fear of rupture, which can have catastrophic results.

For lesions involving the proximal segments of the left subclavian, left common carotid, and especially the innominate artery, we always use a balloon-mounted stent. The chance for compression and deformation of the stent is low. Self-expandable stents are not chosen because of the inability to be exactly precise in a region where millimeters count. Furthermore, there is the possibility of stent migration with the self-expandable stents.

Since 1989, the equipment used to perform subclavian interventions has advanced dramatically, improving technical success, which has been reflected in the high technical success rates, lower complication rates, and lower restenosis rates. Angioplasty alone had a restenosis rate ranging from 5% to 22% (Tables 1 and 2). With the development of endovascular stenting, there has been a reduction in the restenosis rate ranging from 0% to 16% (Table 3).

Intervention of Left Subclavian Occlusions
Gaining access through left subclavian total occlusions is somewhat more difficult and may require a femoral and/or a brachial approach to achieve. We will generally start from the femoral route and, with manipulations of a diagnostic catheter, such as a headhunter or vertebral-shaped catheter, and with a torquable guidewire (regular or stiff Glidewire or Wholey .035-inch guidewire), we will get through most lesions. Attention must be paid, especially with the stiff glide wire, to avoid perforation or dissection of the subclavian artery. Also, care must be taken with the wire crossing the subclavian artery ostium, to be gentle with wire manipulations to avoid causing the wire to dissect across the ostium. If a dissection occurs, stop and have the patient return at a later date.

Once across the lesion, we may change the wire for one with more support. Predilation and balloon-mounted stent placement then proceeds in a manner similar to stenotic lesions.

CHOOSING BETWEEN GUIDING CATHETERS OR SHEATHS
Whether you chose a guiding catheter or a sheath, it is important never to compromise your ability to inject contrast material to visualize the lesion in relation to the balloon catheter. Likewise, it is essential to obtain the best angle to see the takeoff of the vessel in relation to the aorta. It is also crucial to have the best angle to visualize the takeoff of key vessels (vertebral, common carotid, or internal mammary arteries). Because of respiration, roadmap images are not often helpful.

Another feature to be aware of is dramatic aortic pulsations when deploying a stent. If there is a large gap in diastolic and systolic blood pressures, there can be an excess of pulsations of the vessels. These pulsations can cause large motions (1 cm or more) in the position of the lesion relative to the balloon catheter or self-expanding stent when trying to deploy. Blood pressure control is essential in these patients, as well as the need for slightly longer stents.

Distal Subclavian/Axillary Lesions
We are encountering more patients, especially those on hemodialysis, who present with mid and distal subclavian stenosis. We frequently discuss these cases with our vascular surgery colleagues for possible surgical options on a case-by-case basis. When we intervene, we generally prefer to perform angioplasty along those lesions at crucial areas, such as between the first rib and clavicle, as well as at the subclavian/axillary junction where there is bending and compression. When the lesion does not respond to angioplasty, we use self-expanding stents, such as Wallstents (Boston Scientific Corporation, Natick, MA) and nitinol stents. We oversize the stent by 1 mm to 2 mm greater than the vessel diameter and deliver and deploy the stent through a long 7-F to 8-F sheath. Interestingly, there is a lot of slack that must be removed when deploying self-expandable nitinol stents. Furthermore, care must be taken to watch the proximal end of the stent, which tends to jump or shrink farther distally than planned (Figure 6).

Innominate Artery Lesions
The technique for innominate artery lesions is similar to stenting the left subclavian and the left common carotid arteries. Attention must be given to the bifurcation of the right common carotid and the right subclavian arteries (Figure 7). For disease that exists at the origin of the vessels, kissing stents may then be required. There has been some debate regarding the use of distal embolic protection in treating right subclavian artery disease, especially if the disease is close to the ostium of the subclavian artery. We have used distal protection with a filter placed in either the internal carotid artery or the common carotid, depending upon the carotid diameter and filter size available. The 7.5-mm Guidant Accunet (Guidant Corporation, Indianapolis, IN) is often large enough to protect patients with small common carotid arteries.

For more diseased subclavian arteries and for patients requiring a brachial approach, we generally use .014-inch and .018-inch guidewires. There has been a long history of interventions in the subclavian great vessels with very favorable technical success and a relatively low rate of complications. The fortunate low rate of restenosis has also been experienced primarily due to the large size of the vessels.

CONCLUSION
Diagnosis and treatment of occlusive disease of the innominant and subclavian arteries varies depending upon the location of the disease and whether the lesions are highly stenotic or occlusive. Generally, angioplasty and stent placement have been very successful with low complication rates and excellent technical and long-term results. Much of the success depends on improved technology, patient selection, and operator skills. There will be further advances in the treatment of patients with atherosclerotic disease of the innominant and subclavian arteries, as these patients become identified earlier with the growing applications of CT angiography and MRA.

Michael H. Wholey, MD, is a cardiovascular radiologist with Central Cardiovascular Associates of San Antonio and the Department of Cardiovascular and Interventional Radiology at the University of Texas Health Science Center at San Antonio, Texas. He has disclosed that he has served as a consultant and advisor for Edwards Lifesciences and Guidant Corporation. Dr. Wholey may be reached at (210) 271-3203; wholey@uthscsa.edu.

Darren Postoak, MD, is an interventional radiologist at the University of Texas Health Science Center Department of Radiology in San Antonio, Texas. He has disclosed that he holds no financial interest in any product or manufacturer mentioned herein.

Raj Suri, MD, is an interventional radiologist at the University of Texas Health Science Center Department of Radiology in San Antonio, Texas. He has disclosed that he holds no financial interest in any product or manufacturer mentioned herein.

Marco Cura, MD, is an interventional radiologist at the University of Texas Health Science Center Department of Radiology in San Antonio, Texas. He has disclosed that he holds no financial interest in any product or manufacturer mentioned herein.

William Wu, MD, is a clinical professor of cardiology at Central Cardiovascular Associates of San Antonio, Texas. He has disclosed that he holds no financial interest in any product or manufacturer mentioned herein.

Boulos Toursarkissian, MD, is associate professor of surgery and chief of vascular surgery at the University of Texas Health Science Center. He has disclosed that he holds no financial interest in any product or manufacturer mentioned herein.

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