Study Confirms Positive Effect of PAE for Patients With Benign Prostatic Hyperplasia

 

July 21, 2016—Findings from a study that sought to confirm whether prostatic artery embolization (PAE) has a positive medium- and long-term effect in patients with symptomatic benign prostatic hyperplasia (BPH) were published by João M. Pisco, MD, et al in the Journal of Vascular and Interventional Radiology (JVIR; 2016;27:1115–1122).

As summarized in JVIR, between March 2009 and October 2014, 630 consecutive patients with BPH and moderate-to-severe lower urinary tract symptoms refractory to medical therapy for at least 6 months and those who refused any medical therapy underwent PAE. The outcome parameters were evaluated at baseline; 1, 3, and 6 months; every 6 months between 1 and 3 years; and yearly thereafter up to 6.5 years.

In the study, the mean patient age was 65.1 ± 8 years (range, 40–89 years). There were 12 (1.9%) technical failures. Bilateral PAE was performed in 572 patients (92.6%), and unilateral PAE was performed in 46 patients (7.4%). 

The investigators reported that the cumulative clinical success rates at medium- and long-term follow-up were 81.9% (95% confidence interval [CI], 78.3%–84.9%) and 76.3% (95% CI, 68.6%–82.4%). There was a statistically significant (P < .0001) change from baseline to the last observed value in all clinical parameters: International Prostate Symptom Score (IPSS), quality of life (QOL), prostate volume, prostate-specific antigen, urinary maximal flow rate, postvoid residual, and International Index of Erectile Function. There were two major complications without sequelae.

PAE had a positive effect on IPSS, QOL, and all objective outcomes in symptomatic BPH; additionally, the medium- (1–3 years) and long-term (> 3–6.5 years) clinical success rates were 81.9% and 76.3%, with no urinary incontinence or sexual dysfunction reported, concluded the investigators in JVIR.

 

Contact Info

For advertising rates and opportunities, contact:
Craig McChesney
484-581-1816
cmcchesney@bmctoday.com

Stephen Hoerst
484-581-1817
shoerst@bmctoday.com

Charles Philip
484-581-1873
cphillip@bmctoday.com

About Endovascular Today

Endovascular Today is a publication dedicated to bringing you comprehensive coverage of all the latest technology, techniques, and developments in the endovascular field. Our Editorial Advisory Board is composed of the top endovascular specialists, including interventional cardiologists, interventional radiologists, vascular surgeons, neurologists, and vascular medicine practitioners, and our publication is read by an audience of more than 22,000 members of the endovascular community.