Sponsored by Gore & Associates

Case Report: The GORE® EXCLUDER® Iliac Branch Endoprosthesis in a Tortuous Aortoiliac Aneurysm

By Prof. Fabio Verzini, MD, PhD, FEBVS; and Eleonora Centonza, MD
 

Ensuring an adequate proximal and distal landing zone is crucial for a successful and durable endovascular aneurysm repair (EVAR). Abdominal aortic aneurysms (AAAs) associated with common iliac artery (CIA) aneurysm (CIAA) are not uncommon. CIAA is defined by a transverse diameter > 18.5 mm for men and ≥ 15 mm for women and are found in up to 20% of patients diagnosed with an AAA.1 Current suggestions for elective CIAA repair recommend a transverse diameter > 30 mm.2 Standard endografts are not designed to guarantee an adequate distal landing zone in the presence of extensive CIAA, therefore, different endovascular solutions have been proposed to achieve distal sealing with either internal iliac artery (IIA) occlusion or preservation. IIA embolization is associated with erectile dysfunction, buttock or thigh claudication, paraplegia, and sphincter dysfunction in nearly 30% of patients.3 Preservation of at least one hypogastric artery is advisable to reduce the incidence of such complications.4 Initially to maintain endovascular perfusion of the IIA during EVAR, many different techniques have been described using off-the-shelf devices such as the bell-bottom, chimney, sandwich, and double-barrel techniques.5-7 Currently, dedicated iliac branch devices are available* to preserve antegrade perfusion of the hypogastric artery.

CASE PRESENTATION

A 72-year-old man with a history of smoking, obesity (BMI, 38 kg/m2), hypertension, type II diabetes, and severe chronic obstructive pulmonary disease was diagnosed with an asymptomatic aortoiliac aneurysm (55 mm maximum diameter) and a concomitant CIAA of 37 mm with highly tortuous iliac vessels (Figure 1). In consideration of his comorbidities and anatomical features, a total endovascular repair was suggested, discussed, and chosen with the patient.

Figure 1. Preoperative CTA demonstrating the right aortoiliac aneurysm with highly tortuous iliac access.

Figure 2. Deployment of the dedicated internal iliac component in the IBE gate.

Preoperative CTA was analyzed with a dedicated workstation, and planning and sizing was based on centerline flow measurements (Figure 1). A GORE® EXCLUDER® Iliac Branch Endoprosthesis (IBE) was selected to accommodate and navigate the patient’s tortuous iliac anatomy and achieve complete exclusion of the right CIAA. Due to the patient’s obesity, ultrasound-guided bilateral percutaneous femoral access was achieved, and two ABBOTT® PERCLOSE® PROGLIDE Closure Systems for each side were preimplanted for the percutaneous perclose technique. A hydrophilic guidewire with parallel puncture of a 16 Fr introducer sheath was snared from the right to the left femoral access in a through-and-through fashion and then loaded on the precannulated internal iliac artery gate. A 23 x 14 x 100 mm IBE was then deployed into the iliac aneurysm, with the bifurcated component just proximal to the right iliac bifurcation over a Lunderquist guidewire. A 12 Fr COOK® FLEXOR® Introducer Sheath was then advanced from the left femoral access over the through-and-through guidewire in the internal iliac artery gate of the IBE.

Figure 3. Postoperative angiogram documenting complete aneurysm exclusion with no signs of endoleak, patency of the hypogastric arteries, and good conformability of the device to the patient’s anatomy.

After selective cannulation of the superior gluteal artery with a Cobra-shaped 5 Fr CORDIS® Diagnostic Catheter and positioning of an ABBOTT® SUPRA CORE 0.035 inch Guidewire, a Gore 16 x 14.5 x 70 mm Internal Iliac Component was deployed in the IIA (Figure 2). In a standard fashion, a 31 x 14.5 x 160 mm GORE® EXCLUDER® Device Trunk-Ipsilateral Leg Component was deployed in the infrarenal aorta just distal to the renal artery ostia, with a 23 x 100 mm right bridging component to the IBE in the right iliac artery. Lastly, a 20 x 100 mm iliac extender graft was deployed from the left femoral access in overlap with the GORE EXCLUDER Device Ipsilateral Leg.

Postprocedural angiography documented complete exclusion of the aortoiliac aneurysm with no signs of endoleaks, patency of the right iliac branch, and both IIAs (Figure 3) demonstrated good conformability of the IBE to the patient’s tortuous anatomy. The postoperative course was uneventful, and the patient was promptly discharged on postoperative day 2.

Figure 4. Postoperative CTA at 2 years.

Follow-up protocol consisted of a postoperative CTA at 1 month, duplex scan at 6 months, and CTA yearly thereafter. A type II endoleak sustained by lumbar arteries was detected at the first-year CTA with no aortic sac increase, and it is currently under surveillance. The right iliac aneurysm is still completely excluded after 2 years of follow-up with good patency of the IIA (Figure 4).

DISCUSSION

Iliac branch devices have contributed to the expansion of total endovascular repair of extensive aortoiliac aneurysmal disease. Preservation of the antegrade perfusion of the hypogastric arteries is effective in reducing the risk of buttock claudication occurring in about 30% of patients after endovascular repair of CIA with embolization/coverage of the IIA.8-10 Safety and efficacy of iliac branch devices have been investigated with patency rates reported to be over 80% in most of the recent series11-13 in a midterm setting. Long-term durability has been further investigated in a recent series, with freedom from iliac branch–related reintervention of 97.4%, 95.6%, 94.0%, and 91.8% at 1, 3, 5, and 9 years, respectively. Hypogastric artery patency was 94.7%, 92.6%, and 90.4% at 1, 3, and 10 years, respectively.14,15 The IBE is a 16 Fr nitinol and expanded polytetrafluoroethylene new-generation device with a precannulated internal iliac limb and a dedicated iliac internal component designed to improve kink resistance and accommodate a wide range of both external and internal iliac diameters (6.5 to 25 mm and 6.5 to 13.5 mm, respectively) with proven results in iliac patency preservation.16-19

The IBE has to be considered as a first-choice option for total endovascular aortic aneurysm repair in aortoiliac extensive aneurysmal disease, especially in patients with iliac tortuosity, thanks to its high comformability to patient anatomy and the ability to preserve pelvic circulation.20 A tailored approach with accurate preoperative planning and patient selection is strongly recommended for successful and durable endovascular repair. Life-long surveillance is still necessary after graft implantation, as long-term device-specific data are lacking.

1. Huang Y, Gloviczki P, Duncan AA, et al. Common iliac artery aneurysm: expansion rate and results of open surgical and endovascular repair. J Vasc Surg. 2008;47:1203–1210.

2. Moll FL, Powell JT, Fraedrich G, et al. Management of abdominal aortic aneurysms clinical practice guidelines of the European society for vascular surgery. Eur J Vasc Endovasc Surg. 2011;41 Suppl 1:S1-S58.

3. Bosanquet DC, Wilcox C, Whitehurst L, et al; British Society of Endovascular therapy (BSET). Systematic review and meta-analysis of the effect of internal iliac artery exclusion for patients undergoing EVAR. Eur J Vasc Endovasc Surg. 2017;53:534-548.

4. Kouvelos GN, Katsargyris A, Antoniou GA, et al. Outcome after interruption or preservation of internal iliac artery flow during endovascular repair of abdominal aortoiliac aneurysms. Eur J Vasc Endovasc Surg. 2016;52:621-634.

5. Torsello G, Schönefeld E, Osada N, et al. Endovascular treatment of common iliac artery aneurysms using the bell-bottom technique: long-term results. J Endovasc Ther. 2010;17:504–509.

6. Wu IH, Chan CY, Chen YS, et al. Crossover chimney technique to preserve the internal iliac artery in abdominal aortic aneurysm with common iliac artery aneurysms. J Endovasc Ther. 2013;20:298–302. 


7. Lobato AC. Sandwich technique for aortoiliac aneurysms extending to the internal iliac artery or isolated common/internal iliac artery aneurysms: a new endovascular approach to preserve pelvic circulation. J Endovasc Ther. 2011;18:106–111. 


8. Ghosh J, Murray D, Paravastu S, et al. Contemporary management of aorto-iliac aneurysms in the endovascular era. Eur J Vasc Endovasc Surg. 2009;37:182e8.

9. Rayt HS, Bown MJ, Lambert KV, et al. Buttock claudication and erectile dysfunction after internal iliac artery embolization in patients prior to endovascular aortic aneurysm repair. Cardiovasc Intervent Radiol. 2008;31:728-734.

10. Cochennec F, Marzelle J, Allaire E, et al. Open vs endovascular repair of abdominal aortic aneurysm involving the iliac bifurcation. J Vasc Surg. 2010;51:1360-1366.

11. Ferreira M, Monteiro M, Lanziotti L. Technical aspects and midterm patency of iliac branched devices. J Vasc Surg. 2010;51:545-550.

12. Pua U, Tan K, Rubin BB, et al. Iliac branch graft in the treatment of complex aortoiliac aneurysms: early results from a North American institution. J Vasc Interv Radiol. 2011;22:542-549.

13. Donas KP, Torsello G, Pitoulias GA, et al. Surgical versus endovascular repair by iliac branch device of aneurysms involving the iliac bifurcation. J Vasc Surg. 2011;53:1223-1229.

14. Simonte G, Parlani G, Farchioni L, et al. Lesson learned with the use of iliac branch devices: single centre 10 year experience in 157 consecutive procedures. Eur J Vasc Endovasc Surg. 2017;54:95-103.

15. Parlani G, Verzini F, De Rango P, et al. Long-term results of iliac aneurysm repair with iliac branched endograft: a 5-year experience on 100 consecutive cases. Eur J Vasc Endovasc Surg. 2012 Mar;43:287-292.

16. Bos WT, Tielliu IF, Van Den Dungen JJ, et al. Results of endovascular abdominal aortic aneurysm repair with selective use of the Gore Excluder. J Cardiovasc Surg. 2009;50:159–164.

17. Bastos Goncalves F, Rouwet Ellen V, Metz R, et al. Device-specific outcomes after endovascular abdominal aortic aneurysm repair. J Cardiovasc Surg. 2010;51:515–531.

18. Schneider DB, Matsumura JS, Lee JT, et al. Prospective, multicenter study of endovascular repair of aortoiliac and iliac aneurysms using the Gore Iliac Branch Endoprosthesis. J Vasc Surg. 2017 May 27.

19. Parlani G, Verzini F, De Rango P, et al. Long-term results of iliac aneurysm repair with iliac branched endograft: a 5-year experience on 100 consecutive cases. Eur J Vasc Endovasc Surg. 2012;43:287-292.

20. Della Schiava N, Arsicot M, Boudjelit T, et al. Conformability of GORE Excluder iliac branch endoprosthesis and COOK Zenith bifurcated iliac side branched iliac stent grafts. Ann Vasc Surg. 2016;36:139-144.

Prof. Fabio Verzini, MD, PhD, FEBVS
Associate Professor of Vascular Surgery
University of Perugia
Vascular Surgery Unit
S. Maria della Misericordia Hospital
Perugia, Italy
+39 075 5786435; fabio.verzini@unipg.it
Disclosures: Consultant for Gore & Associates, Medtronic, and Cook Medical.

Eleonora Centonza, MD
Vascular Surgery Unit
S. Maria della Misericordia Hospital
Perugia, Italy
Disclosures: None.

 

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