Nylon Fibered Versus Nonfibered Embolization Coils Compared in Porcine Study
April 10, 2019—A study to determine whether nylon fibers improve the performance of platinum embolization coils in porcine arteries was published by Scott O. Trerotola, MD; Gary A. Pressler, PhD; and Christopher Premanandan, DVM, online ahead of print in Journal of Vascular and Interventional Radiology (JVIR). The platinum embolization coils, guidewires, and catheters used were from Cook Medical, which funded the study.
The investigators found that nylon fibers allow significantly fewer embolization coils to achieve acute occlusion of arteries compared to bare-metal coils; additionally, they noted that both fibered and nonfibered coils showed recanalization at follow-up.
As outlined in JVIR, investigators used 0.035-inch platinum embolization coils, both with and without nylon fibers, to embolize a total of 24 hindlimb arteries in six swine: 12 with fibered coils and 12 with nonfibered coils. The coils were identical except for the fibers. The investigators evaluated immediate and late results, including the number of coils needed to achieve vessel occlusion and durability of occlusion at 1 and 3 months. They performed arteriography as well as histopathologic analysis.
The investigators reported the following in JVIR:
- A mean of 3.2 (range, 2–4) nonfibered coils were required to achieve occlusion, whereas a mean of 1.3 (range, 1–2) fibered coils achieved occlusion in similarly sized arteries (2.3- to 3.2-mm diameter; P < .001).
- The mean percent cross-sectional area occupied by thrombus was greater in arteries with fibered coils than with nonfibered coils at 1 month (63% ± 6% and 48% ± 15%, respectively; P = .03) but not at 3 months (61% ± 6% and 49% ± 15%, respectively; P = .06).
- Some recanalization was observed at follow-up and did not differ between groups at 1 month (P = .07) or 3 months (P = .22).