CUC and Dr. Yuji Okuno Partner to Expand to Musculoskeletal Embolotherapy in the United States

November 12, 2025—CUC Inc., a provider of health care management and operational support services headquartered in Tokyo, Japan, announced it has signed a Memorandum of Understanding (MOU) with Yuji Okuno, MD, to form a strategic partnership for the expansion of chronic pain treatment business in the United States. Dr. Okuno is Chief Director of Okuno Clinic and Chairman of the Yuyu-kai Medical Corporation.

According to CUC, the partnership aims to deliver Dr. Okuno’s minimally invasive catheter-based treatment—transcatheter arterial micro embolization (TAME)—that targets abnormal neovessels (called “Moyamoya vessels” in Japan) through CUC’s newly developed office-based laboratories (OBLs) in the United States.

CUC advised it plans to open approximately 20 OBL locations nationwide within the next 3 years.

Dr. Okuno’s interventional TAME therapy was developed to address conditions long considered untreatable, such as chronic shoulder stiffness, frozen shoulder, knee osteoarthritis, chronic prostatitis, Heberden’s nodes, and pain associated with internal hemorrhoids. The therapy targets inflammation through the blood vessels using a minimally invasive technique, noted the CUC press release.

Under the MOU, CUC will accelerate the rollout of Dr. Okuno’s treatment across the United States through the following initiatives:

• CUC will adopt an OBL model that combines patient convenience with advanced technical capability. The company plans to open 5 to 7 locations in the first year and approximately 20 within 3 years.
• In parallel with site expansion, CUC will develop training programs for United States–based physicians and nurses to ensure consistent delivery of high-quality care based on Dr. Okuno’s protocol.
• CUC participated in the VENTI 2025 international conference in Tokyo from November 7 to 8, 2025, as its kick-off event to build partnerships with leading clinicians from the United States and other countries. VENTI—Vascular Embolotherapy and Nerve Interventions Targeting Inflammation and Pain—is organized by Dr. Okuno and Professor Gerard Goh, MD, of Monash University in Melbourne, Australia.