Femoropopliteal Artery Stent Thrombosis Evaluated in XLPAD Registry

March 23, 2016—A report from the Excellence in Peripheral Artery Disease (XLPAD) registry evaluating the incidence of stent thrombosis in femoropopliteal artery interventions was published Subhash Banerjee, MD, et al online ahead of print in Circulation: Cardiovascular Interventions. More information about the registry is available online at http://www.xlpad.org.

Index procedures resulting in femoropopliteal stent thrombosis were compared with stent procedures without subsequent stent thrombosis in the XLPAD registry. The study data had a total of 724 cases of stent procedures and 604 unique patients.

As summarized in Circulation: Cardiovascular Interventions, femoropopliteal stent thrombosis occurred in 26 of 604 patients (4.3%) over a median follow-up of 6 months postprocedure. The investigators also found that stent thrombosis was more likely to occur in men and to have an initial intervention for chronic total occlusions.

There was no significant difference in stent thrombosis between drug-coated and bare-metal stents, but the rate of stent thrombosis was significantly higher with self-expanding covered stent grafts compared with bare-metal stents. Stent thrombosis was significantly associated with an increased risk of 12-month major adverse limb events compared with no stent thrombosis.

Multivariate analysis showed that treatment of chronic total occlusion lesions and in-stent restenosis lesions were independently associated with an increased risk of stent thrombosis, reported the investigators in Circulation: Cardiovascular Interventions.