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CREST: Addressing Frequently Asked Questions
CREST Principal Investigator Thomas G. Brott, MD, and Project Director Alice Sheffet, PhD, address a few of the common questions regarding the landmark carotid revascularization trial.
CREST Update
Meeting the challenges of a randomized clinical trial.
By Susan E. Hughes, BSN; MeeLee Tom, MS; Mary E. Longbottom, BA; Alice J. Sheffet, PhD; Thomas G. Brott, MD; and Robert W. Hobson II, MD
CREST Achieves Major Milestone
An update of new data regarding asymptomatic participants.
By Jamie Roberts, BSH, CCRP; Susan Hughes, BSN; MeeLee Tom, MS; Jason Avery, MPH; Alice Sheffet, PhD; Thomas G. Brott, MD; and Robert Hobson, MD
CREST-2: Guiding Treatments for Asymptomatic Carotid Disease
Examining stenting and endarterectomy in the context of intensive medical management.
By Brajesh K. Lal, MD; James F. Meschia, MD; and Thomas G. Brott, MD
CREST Published in NEJM
May 26, 2010—Thomas G. Brott, MD, et al published the CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) study results online ahead of print in the New England Journal of Medicine. The data were presented for the first time on February 26 at the International Stroke Conference 2010 in San Antonio, Texas and were reported at that time by Endovascular Today (2010;9:12–16).
Updates From the Investigators
Principal investigators from four major US and international carotid artery therapy clinical trials discuss their latest developments, progress to date, and long-term goals.
CREST Results Published in NEJM Show Equivalence of CAS to CEA
May 26, 2010—The CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) study results were published by Thomas G. Brott, MD, et al online ahead of print in the New England Journal of Medicine. The data were presented for the first time on February 26 at the International Stroke Conference 2010 in San Antonio, Texas and were reported at that time by Endovascular Today.
SCAI Calls for Expanded Coverage for Carotid Artery Stenting
May 26, 2010—The Society for Cardiovascular Angiography and Interventions (SCAI) stated that the results from the CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) study published by Thomas G. Brott, MD, et al online ahead of print in the New England Journal of Medicine should convince the Centers for Medicaid & Medicare Services (CMS) to reopen its coverage decision to give carotid artery stenosis patients an opportunity to choose carotid artery stenting (CAS) and allow physicians to tailor treatments for the best possible outcome. The evidence now strongly supports individualizing treatment and offering stent coverage so that more patients who may benefit from this safe, effective, and less-invasive treatment can have access to it, SCAI stated.
CREST-2 Completes Enrollment
August 13, 2024—CREST-2, the Carotid Revascularization Endarterectomy or Stenting Trial, has completed patient enrollment.
CAS and CEA Show Equal Safety and Efficacy at Lowering Long-Term Stroke Risk in 10-Year CREST Results
March 21, 2016—The Mayo Clinic in Jacksonville, Florida, recently announced that the 10-year findings from the CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) study demonstrated that stenting and surgery are equally effective at lowering the long-term risk of stroke from a narrowed carotid artery.
Protocol for CREST-2 Trial Published
May 4, 2017—The protocol for the Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) was published online ahead of print in the International Journal of Stroke by Virginia J. Howard, PhD, et al on behalf of the CREST-2 study investigators.
CREST Data Show Equivalence Between CAS and CEA
February 26, 2010—Long-awaited results from the CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) study were presented today for the first time at the American Stroke Association's Annual International Stroke Conference 2010, which convened on February 24–26 in San Antonio, Texas.
An Interview with Kenneth Rosenfield, MD
An expert asserts the importance of trials and registries, reflecting on lessons learned from his own experience, and discusses this year's VIVA meeting.
Multisociety Guidelines Issued on Management of Extracranial Carotid and Vertebral Artery Disease
January 31, 2011—New multisociety practice guidelines on the management of patients with extracranial carotid and vertebral artery disease have been issued that reinforce the safety and efficacy of carotid artery stenting (CAS) as an option for patients in need of revascularization.
Abbott Vascular to Seek Expanded Indication for CAS With Acculink System Based on CREST Data
May 26, 2010—Abbott Vascular (Santa Clara, CA) announced that based on the strength of data from the CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) study, which used the company's Acculink carotid stent system and Accunet embolic protection system, the company will seek an expanded indication from the US Food and Drug Administration (FDA) for the Acculink carotid stent system as a treatment option for patients at standard surgical risk.
CREST Shows Equivalence Between CAS and CEA
February 26, 2010—Long-awaited results from the CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) study were presented for the first time at the International Stroke Conference 2010.
FDA Advisory Panel Recommends Expanded CAS Indication for Abbott Vascular's RX Acculink
By The Endovascular Today Staff
January 26, 2011—Abbott Vascular (Santa Clara, CA) announced that the US Food and Drug Administration (FDA) Circulatory System Devices Panel of the Medical Devices Advisory Committee voted that, for symptomatic and asymptomatic carotid artery disease patients at standard surgical risk, there is reasonable assurance that the benefits of carotid artery stenting (CAS) with the company's RX Acculink carotid stent system outweigh its risks.
The State of CAS
By William A. Gray, MD, and Sumaira Macdonald, MBChB, FRCP, FRCR, PhD
The Ongoing Pursuit of Data
By John R. Laird, Jr, MD, Chief Medical Editor
