Retrograde Recanalization of the Celiac Trunk
Treatment of a type A aortic dissection and a discussion of the available options.
Arterial obstruction in patients with aortic dissection can be caused by the dissection flap itself (either dynamic or static), distal embolization, occlusion of a vessel arising from the false lumen, thrombosis in a region of stasis, or problems caused by a pre-existing arterial stenosis.
Treatment options consist of surgical repair and endovascular repair. Stent graft placement is indicated in cases of malperfusion of the true lumen and its branches. In some cases, however, the extension of the dissection does not permit safe stent graft placement. This article describes a case of extension of the intimal flap in a patient with a type A dissection into the celiac trunk, leading to occlusion.
A 44-year-old man was referred to our center with a type A dissection extending from the aortic valve to the aortic bifurcation. Emergent surgical repair consisting of aortic valve and ascending thoracic aorta replacement was performed. The distal part of the dissection was not treated surgically, and medical therapy was started in order to lower blood pressure. In the immediate postoperative period, the patient developed a compartment syndrome caused by transient hypoperfusion of the right lower leg, necessitating a fasciotomy. At postoperative day 12, the patient developed clinical signs of gastric ischemia (laboratory findings: ASAT/GOT, 217 u/L; ALAT/GPT, 432 u/L; G-GT, 234 u/L; LDH, 1,976 u/L; CK, 1,272 u/L). Computed tomographic (CT) angiography was performed, which revealed occlusion of the celiac trunk, probably with thrombus in the main stem of the celiac axis; the celiac axis was originating from the true lumen (Figure 1A).
Because of thrombus, treatment with (percutaneous) fenestration was not considered as a viable treatment option, and the patient was scheduled for percutaneous revascularization. After right common femoral artery access (4-F sheath) was achieved, the celiac trunk was cannulated selectively, confirming an occlusion (Figure 1B). Several attempts to cross the occlusion in an antegrade fashion were unsuccessful. Selective catheterization of the superior mesenteric artery with a Cobra-type catheter demonstrated retrograde filling of the celiac trunk through pancreaticoduodenal and gastroduodenal collaterals (Figure 1C). Therefore, we decided to attempt a retrograde recanalization.
An exchange was made for a Simmons I-type diagnostic catheter. With the use of a Y-connector (to allow for continuous flushing) and a microcatheter (Progreat 2.7 F, 130 cm, Terumo Interventional Systems, Somerset, NJ), a coaxial catheter system was created. The microcatheter and its guidewire were subsequently advanced until the tip of the microcatheter could not be advanced anymore because of the lack of length (Figure 1D, E). An exchange of the Progreat guidewire for a longer guidewire (0.014-inch, 300-cm ATW, Cordis Corporation, Warren, NJ) was made, and this wire was advanced across the origin of the celiac trunk into the aorta (Figure 1F). At this point, a second arterial access of the ipsilateral common femoral artery was obtained (6-F sheath). A 4-F loop snare catheter (Amplatzer Goose Neck snare kit, 4 F, 120 cm, ev3 Inc., Plymouth, MN) was advanced over a guidewire to the level of the celiac trunk, and after removal of the guidewire, the snare was advanced. The 0.014-inch guidewire protruding from the celiac axis was snared (Figure 2A), and the snare and its catheter were pulled into the celiac axis by traction on the 0.014-inch guidewire (Figure 2B). The snare and its catheter were advanced into the inferior pancreaticoduodenal artery and subsequently into the aorta, and at that point, the snare and the 0.014-inch guidewire were disengaged (Figure 2C through E). The snare was removed and replaced for a 0.018-inch guidewire (SV-5, 180 cm, Cordis Corporation).
After removing the snare kit catheter, a 6-F guiding catheter (RDC, Cordis Corporation) was advanced over the 0.018-inch guidewire, and subsequently, a balloon-expandable stent (Palmaz Blue, 7 X 12 mm, Cordis Corporation) was placed (Figure 3A). Stent placement was uneventful, but control angiography revealed propagation of the thrombus distally into the celiac axis (Figure 3B). Additional balloon angioplasty (Savvy 6 X 40 mm, Cordis Corporation) at the level of the thrombus was performed, and control angiography demonstrated optimal reconstitution of flow (Figure 3C).
The clinical course was complicated by rhabdomyolysis (as a sequelae of the compartment syndrome), necessitating temporary hemofiltration. The signs of gastric ischemia disappeared, and the patient demonstrated normal intestinal peristalsis. The patient was dismissed in good clinical condition on day 56.
Aortic dissection is a life-threatening disease with a high mortality rate and an elevated incidence of early and long-term complications.1 Most cases of acute type A dissection are managed surgically.
Most cases of acute type B dissection are managed medically, although open surgery or stent graft placement is sometimes performed. Patients with type B or surgically treated type A dissection may develop vascular complications, such as mesenteric or peripheral ischemia, which cannot be managed medically. In these cases, arterial obstruction can be caused by the dissection flap itself (either dynamic or static), distal embolization, occlusion of a vessel arising from the false lumen, thrombosis in a region of stasis, and problems caused by a pre-existing arterial stenosis.2,3
Treatment options consist of surgical repair and endovascular repair. Stent graft placement is indicated in cases of malperfusion of the true lumen and its branches. In some cases, however, the extension of the dissection does not permit safe stent graft placement. The contraindications for endovascular treatment using a stent graft are most often related to anatomic considerations. Stent graft placement requires adequate vascular access (sufficient diameter of the iliac artery and abdominal aorta without severe tortuosity), an aortic lesion without excessive tortuosity, a neck that extends more than 15 mm above the celiac artery and is more than 5 mm distal to the left subclavian artery without mural thrombus (more than 50% of patients present with thrombosis of the false lumen), and dilatation.4 Other contraindications include a tear too proximal to crucial branch vessels, inadequate seal of the stent graft, or unavailability of an adequate size stent graft. In cases of ischemic complications related to aortic dissection in which contraindications for stent graft placement exist, alternative treatment options such as fenestration and stent placement should be employed.5 The goal of these therapies is to allow outflow from the false lumen, to relieve branch vessel obstruction, to reduce intraluminal pressure, and to reduce the risk of extension of the dissection.
Fenestration is a method to decompress the hypertensive false lumen by creating a hole in the distal part of the dissection flap, thus augmenting flow in the true lumen (and its branches that are at risk).6 Fenestration is the first choice treatment option.
Two different techniques to create and enhance communication between the true and false lumen exist:
Balloon technique. With this technique, a guidewire is placed across an existing communication between the false and true lumen (either going from true to false or vice versa); a large size balloon (> 15 mm) is used to enlarge the pre-existing hole.
Creation of a novel communication by puncturing the intimal flap using the back end of a guidewire or needle systems as used in TIPS procedures (transjugular intrahepatic portosystemic shunt). Puncture guidance can be performed using a loop snare in the false lumen as a target, with multiplanar or three-dimensional rotational angiography, or transesophageal echocardiogram or intravenous ultrasound; subsequently, the puncture hole is enlarged, as described above.
Scissor technique. With this technique, the arterial system is accessed at a point beyond the dissection with a 6- or 7-F introduction sheath. Selective cannulation of the true and false lumen is performed, and guidewires are left in place. A guiding catheter is then advanced over both guidewires and will tear the intimal flap in a longitudinal fashion.5
It is of utmost importance to measure intra-arterial pressure within the true and false lumen. The aim is to reduce the pressure gradient to less than 5 mm Hg. If this objective cannot be reached, a second angioplasty with a larger balloon or a second fenestration can be performed.
Complications of fenestration procedures include dehiscence of intimal flap (on CT angiography presenting as a tube-in-tube sign), aneurysm formation, transmural perforation, and propagation of dissection.7,8
Indications for stent placement are the presence of static dissection (ie, extension of dissection up to and/or into the aortic side branch in the absence of a re-entry tear, resulting in constriction of lumen) into a branch vessel only. This can be performed by direct access, in a way similar to stent placement in cases of atherosclerotic stenotic disease. If the occlusion cannot be recanalized in an antegrade fashion, collaterals can be used to perform a retrograde recanalization.
Other indications for stent placement are persisting pressure gradient after fenestration, the presence of significant thrombus in the false lumen (this increases the risk of embolization during fenestration procedures), and failure to perform a fenestration.
It must be kept in mind that stent placement (especially in the false lumen) might compromise future thoracic surgery. Technical success can be achieved in up to 90% of cases, with a clinical success rate of 43% to 91%.6,9 About one-third of patients die in cases of visceral artery involvement.
Aortic dissection can be complicated by occlusion of visceral side branches, which may lead to life-threatening visceral ischemia. Several surgical and endovascular treatment options are available. Retrograde recanalization is one of the treatment options that should be kept in mind when treating this category of patients.
Rafael Trunfio, MD, is with the Service of Cardiac Surgery, Cardiocentro Ticino, in Lugano, Switzerland. He has disclosed that he holds no financial interest in any product or manufacturer mentioned herein.
Francesco Siclari, MD, is Head of Service of Cardiac Surgery, Cardiocentro Ticino, in Lugano, Switzerland. He has disclosed that he holds no financial interest in any product or manufacturer mentioned herein.
Jos C. van den Berg, MD, PhD, is Head of Service of Interventional Radiology, Ospedale Regionale di Lugano, sede Civico in Lugano, Switzerland, and Associate Professor of Vascular Surgery at the University of Pisa, Italy. He has disclosed that he holds no financial interest in any product or manufacturer mentioned herein. Dr. van den Berg may be reached at +41 91 811 6072; firstname.lastname@example.org.