Within the past 20 years, there has been a veritable paradigm shift in the treatment of cerebral aneurysms. During this time, our understanding of the pathophysiology and clinical risk profile of these lesions in combination with technologic progress has led to a more nuanced approach to aneurysms. Previously, treatment was directed toward immediate physical and radiographic obliteration of an aneurysm via microsurgical clipping in order to minimize the risk and mortality associated with aneurysmal rupture or rerupture. With the advent of the Guglielmi detachable coil (Boston Scientific Corporation), an endovascular means to accomplish these goals arose. The ISAT 1 and 2 and BRAT trials affirmed clinical equipoise and, in some cases, superiority of endovascular embolization to open surgical clipping in the treatment of ruptured cerebral aneurysms.1-6 Combined with further natural history data on the rupture risks of untreated aneurysms, these data provide the background for an informed risk-benefit discussion regarding the treatment of cerebral aneurysms.7,8

Despite these advances, large-necked, giant, and fusiform aneurysms remained a vexing problem. Giant aneurysms represented a challenge surgically, especially in regions where surgical access is associated with unacceptable morbidity (eg, the cavernous segment), and coil embolization presents a technical challenge.1,8 Frequently, coiling alone results in insufficient embolization of the lesion, and coil compaction leads to very high recurrence rates. Adjunctive measures such as balloon- and stent-assisted coiling were necessary to achieve occlusion. However, even with these measures, there was a high risk of recurrence in these large, broad-based lesions. Unlike smaller lesions, the inability to achieve the necessary coil packing for cure leads to their recurrence, growth, and rupture in some instances.

Beyond saccular lesions, fusiform aneurysms of both the anterior and posterior circulation present an even greater challenge. Open surgery relies on vessel clip reconstruction or vessel sacrifice with or without bypass. These strategies are rife with risk that in many instances can equal the risk of the lesion itself. With previously available devices, endovascular options were largely limited to vessel sacrifice. Multiple stents, which were used as an adjunctive measure for coil support, were occasionally placed successively to attempt endovascular luminal interruption of flow to the lesion.9 This presented a challenge because multiple devices were needed, increasing the thromboembolic and procedural risk of treatment.


Flow diversion arose as a concept for the treatment of aneurysms using endoluminal methods, and flow diversion devices were developed with the hope that vessel reconstruction may present an alternative to the clip/coil paradigm. Flow diversion relies on reestablishing normal flow through the parent vessel and reducing flow through the aneurysmal lesion, which leads to progressive occlusion of the aneurysm and endothelialization along the device.10,11 These devices are low-porosity stents that rely on the flow differential maintained between the parent and daughter vessels versus the pathologic flow into an aneurysmal lesion.

Unlike in microsurgical clipping and coil embolization, where the aneurysm is immediately obliterated, flow diversion relies on changes in the flow dynamics within aneurysms to cause aneurysmal thrombosis over time and allow for neointimal proliferation to eventually seal off an aneurysm.11-13 As an intraluminal device, flow diverters themselves possess thrombotic risk prior to endothelialization. Therefore, dual antiplatelet loading is needed before device implantation and should be continued 3 to 6 months after deployment, which creates an additional nuance.14,15 The need for dual antiplatelet therapy should be further considered for potential hemorrhagic complications (eg, subarachnoid hemorrhage, distal intraparenchymal hemorrhage). Fortunately, aneurysmal rupture remains a small concern with these devices and is seen in only 2% to 4% of cases. Distal hemorrhage related to the placement of the device remains a concern, as these complications were observed in 5% to 10% of treated patients with giant aneurysms.11-13,16-19

Current controversy exists as to the ideal regimen, choice of regimen, and timing of discontinuation of dual antiplatelet therapy.14 Beyond the risk of thromboembolism, the risk of in-device occlusion or delayed stenosis and occlusion of side branches are also concerns. Fortunately, animal models and retrospective studies have repeatedly demonstrated the safety of these devices over larger daughter vessels when the device is in the internal carotid artery and covers the ophthalmic artery, a daughter vessel; studies in rabbits have demonstrated that the ophthalmic artery does not occlude. Studies examining the patency and durability of flow through the ophthalmic, posterior communicating, and anterior choroidal arteries have demonstrated the clinical safety of these devices. Vessel occlusion occurred in fewer than 5% of patients, and of those with occluded vessels, none demonstrated clinical deficit as a result.20-25


Initially, clinical indications for the application of flow diversion devices focused on previously untreatable or poorly treatable lesions and large/giant wide-necked aneurysms of the anterior circulation. Several feasibility trials across multiple international centers demonstrated an almost 99% deployment success rate and a 75% occlusion rate in the treatment of giant lesions proximal to the internal carotid artery bifurcation and recurrent lesions.12,16,26,27 The success of these studies led to the US Food and Drug Administration (FDA) approval of the Pipeline embolization device (PED; Medtronic) for use in anterior circulation aneurysms. Presently, PED and its second generation, the Pipeline Flex, are the only flow diverters available in the United States. Internationally, the Silk device (Balt Extrusion), p64 flow modulation device (phenox GmbH), Flow Re-direction Endoluminal Device (FRED; MicroVention Terumo), and Surpass device (Stryker) are available.28


In concert with the FDA approval, flow diverters are mainly used to treat lesions of the anterior circulation proximal to the internal carotid artery (ICA) bifurcation. Figure 1 demonstrates an on-label use of the PED for the treatment of a large irregular cavernous artery aneurysm. “Telescoped” devices are used to span the large neck of a fusiform giant aneurysm. The immediate reduction in aneurysm filling and size and ultimate vessel remodeling with flow diversion is apparent, demonstrating the ability of these devices to treat previously untreatable lesions. Flow diversion is successful in reducing the initial flow into an aneurysm and further leading to complete thrombosis.11,18,29,30 Figure 1 demonstrates the effectiveness of these devices in treating these lesions, which previously were either difficult to treat or completely eradicated.

Figure 1. A 77-year-old woman presented with left eye ophthalmoplegia and orbital pain and was found to have a giant 25- X 20-mm cavernous ICA aneurysm (A). Two telescoping PEDs were placed through the lesion with immediate evidence of stasis within the aneurysm (B). Six-month follow-up imaging shows remodeling of the vessel with near-resolution of the lesion (C).

With time and familiarity, flow diversion devices are increasingly being used for smaller, broad-based lesions that would otherwise be difficult to approach endovascularly. Flow diversion presents a solution to recurrent and remnant aneurysms after attempted coil embolization or microsurgical clipping. Previously, the principle driving force for treatment of an aneurysm (ruptured or unruptured) was to achieve complete occlusion of the lesion or a Raymond–Roy classification 1 or 2 result.31-34 The use of Guglielmi detachable coils alone within narrow necked saccular lesions effectively achieves this goal.

However, for broad-necked lesions, the ability to achieve sufficient coil packing within the lesion is often compromised.1,4-6,35 Adjunctive measures such as balloon-assisted coiling and stent coiling can often support the addition of more coils, yet recurrence and coil compaction remains a significant problem.36-38 Flow diversion provides an alternative mechanism to thrombose an aneurysm and to reconstruct a vessel lumen. Case-controlled studies have explored the use of flow diversion versus coil embolization for anterior circulation lesions and found a greater rate of occlusion for lesions treated with PED compared to coiling (94% vs 71%) with an equivalent safety profile.39 The concept of promoting lesional thrombosis and providing a scaffolding to reconstruct the native vessel may demonstrate the increased utility of these devices. On the other hand, recent randomized trials, specifically the FIAT trial, demonstrated less than favorable outcomes in patients randomized to flow diversion, with approximately 10% mortality.40 This information needs to be taken in context of previous clinical experience but serves to show that flow diversion does not totally replace the need for other endovascular or surgical techniques.


Figure 2. A 62-year-old woman with a prior subarachnoid hemorrhage secondary to a posterior communicating artery aneurysm presented with an ipsilateral 4-mm anterior choroidal lesion and coil compaction of the posterior communicating lesion (A). A single PED was placed, and 6-month follow-up demonstrated complete occlusion of both lesions (B).

Incomplete treatment and recurrence of aneurysms despite initial treatment due to either aneurysmal growth or coil compaction is a topic well described within the endovascular literature. Initial coil embolization or stent-coil embolization do not preclude other mechanisms of further treatment. More coils, stents, or flow diversion remain options. However, after placement of a flow diverter, additional coil embolization is not feasible because the decreased porosity of these devices does not allow access to the aneurysms with a microcatheter.15,24,41,42 As such, when a remnant or residual lesion is encountered, the only available treatment is placement of an additional flow diverter, which carries further risk to perforators and side branches depending on the parent vessel. Figure 2 illustrates the utility of flow diversion in treating recurrent and broad-based lesions.

For lesions in which there is concern for flow diversion to completely occlude the aneurysm, adjunctive coil embolization should be considered. As previously mentioned, coil embolization is performed through separate catheterization and jailing of the coil microcatheter underneath the flow diverter. Adjunctive coils are placed to promote thrombosis to optimize aneurysm treatment.39,43 Figure 3 demonstrates a ophthalmic segment lesion with concerning features that was successfully treated by flow diversion with adjuvant coiling to promote thrombosis.

Figure 3. A 55-year-old woman who was incidentally found to have a 12- X 7-mm right ophthalmic segment ICA aneurysm with several blebs and irregular dome (A). This was managed with a combination of flow diversion and adjuvant coil embolization due to the concerning features of the lesion (B, C). Six-month follow-up demonstrated complete resolution of the lesion (D).


Cranial nerve palsies secondary to mass effect from a cerebral aneurysm present a challenge specifically to the endovascular surgeon. Open surgical obliteration relieves aneurysmal mass effect, which leads to rapid amelioration of the cranial nerve compression in most cases.44 Unfortunately, previous endovascular methods often led to continued compression rather than treatment of aneurysmal mass effect. Recent case studies have demonstrated the efficacy of flow diversion in treating the aneurysm and relieving cranial nerve deficits, owing to the remodeling effect of these devices over time.45,46 This allows for endovascular treatment of lesions previously requiring open surgery.


Fusiform, broad-based, and complex lesions are not limited to the proximal ICA. Within the initial experience with flow diversion, use within the distal anterior circulation was limited. Yet, with broader experience with the device, several case reports have demonstrated the feasibility and efficacy of flow diversion devices within the anterior and middle cerebral artery.41,47-49 Flow diversion is a treatment option in these complex lesions, but broader recommendations are pending further clinical experience.


Despite its success within the anterior circulation, there remains trepidation to use flow diversion in the treatment of lesions of the vertebrobasilar system. As an intraluminal device with decreased porosity, there is a risk of causing side vessel (ie, perforator vessel) occlusion, which may have devastating consequences in the posterior circulation. Although the use of flow diversion was initially limited within the posterior circulation, there were significant complications.25,50-52 In a series of 101 patients by Fischer et al, three of five major complications occurred in the posterior circulation, including in-device thrombosis and associated hemorrhage.53 Further, a perforator infarction rate of 14% has been observed even in more recent studies. However, as previously discussed in the anterior circulation, many lesions in the posterior circulation are insufficiently treated or incapable of treatment by open surgical techniques or coiling alone. In recent case series, acceptable treatment results demonstrating a near 90% occlusion rate have been reported.54


The use of intraluminal devices in the setting of aneurysmal rupture presents a unique challenge. Ruptured aneurysms represent inherently unstable vascular lesions and are frequently accompanied by intraventricular hemorrhage and hydrocephalus, necessitating cerebrospinal fluid diversion. Typically, endovascular and open surgical treatments immediately secure the lesion without requiring anticoagulation or antiplatelet treatment. Some vascular lesions are suboptimally treated with either open surgery or coiling alone, and flow diversion presents an additional option in these exceptional circumstances. However, hemorrhagic and thromboembolic risks need to be balanced and considered when using these novel devices.15,18,55-57


Figure 4. A 39-year-old man presented with a “worst headache of life.” CTA was negative for subarachnoid hemorrhage, but angiography later revealed a blister ICA communicating segment aneurysm (A). The patient was given aspirin 325 mg and prasugrel 30 mg, and two overlapping PEDs were placed. Follow-up at 6 months demonstrated slight vessel narrowing but obliteration of the lesion (B).

Blister lesions are rare but notoriously difficult to treat via previously available open or endovascular techniques. Blister aneurysms are small lesions (< 2 mm) and are thought to be the manifestation of an overall diseased vessel leading to subarachnoid hemorrhage.58-60 Due to their small size and possible false wall structure, coiling and or stent coiling is challenging and often does not fully secure the lesion or prevent further aneurysmal rupture. Further, open surgery with either clipping or muslin/muscle wrapping can have poor results. Flow diversion as a principle presents an ideal alternative to treat these lesions because it allows for vessel remodeling over time (Figure 4). Retrospective studies have demonstrated early success in treating these difficult lesions.61,62



As with all open and endovascular interventions, flow diversion is not without its own risks. Beyond the ischemic risks, there is a small but real risk of hemorrhage associated with the device. These are related to mechanical complications, aneurysmal rupture, and cryptogenic hemorrhage. Mechanical complications are the most modifiable of these risks. With increased experience with flow diversion and newer-generation devices, an improved safety profile and improved overall outcomes have been demonstrated.27,42,52,55,63-66

Aneurysmal rupture is thought to be due to a transient increase in aneurysmal flow as a result of device placement.13,18,19 Although the risk is small, some centers use adjunctive coiling to promote thrombosis and mitigate this risk (Figure 2). Finally, cryptogenic hemorrhage or distal parenchymal hemorrhage associated with device placement is a rare complication observed with use of these devices.67 Presently, these complications are thought to be a result of the hemorrhagic conversion of embolic stroke associated with dual-antiplatelet therapy required for device placement or associated hyperperfusion. With approximately 100 cases reported in the literature, there appears to be an increased association when multiple devices are required to treat giant aneurysms.68-70


The addition of flow diversion to the endovascular armamentarium not only allows for a new means of treatment, but also a change in the thought process of aneurysm treatment. These devices have expanded the horizons of the endovascular neurosurgeon and improved the treatment of previously difficult-to-treat lesions. Further study is needed to understand the expanded indications of flow diversion devices and their long-term durability.

1. Molyneux A, Kerr R, Stratton I, et al. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet. 2002;360:1267-1274.

2. Molyneux AJ, Birks J, Clarke A, et al. The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT). Lancet. 2015;385:691-697.

3. Molyneux AJ, Kerr RS, Yu LM, et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet. 2005;366:809-817.

4. McDougall CG, Spetzler RF, Zabramski JM, et al. The Barrow Ruptured Aneurysm Trial. J Neurosurg. 2012;116:135-144.

5. Spetzler RF, McDougall CG, Albuquerque FC, et al. The Barrow Ruptured Aneurysm Trial: 3-year results [published erratum appears in J Neurosurg. 2014;120:581]. J Neurosurg. 2013;119:146-157.

6. Spetzler RF, McDougall CG, Zabramski JM, et al. The Barrow Ruptured Aneurysm Trial: 6-year results. J Neurosurg. 2015;123:609-617.

7. Unruptured intracranial aneurysms—risk of rupture and risks of surgical intervention. International Study of Unruptured Intracranial Aneurysms Investigators [published erratum appears in N Engl J Med 1999;340:744]. N Engl J Med. 1998;339:1725-1733.

8. USAS Japan Investigators, Morita A, Kirino T, et al. The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med. 2012;366:2474-2482.

9. Fiorella D, Albuquerque FC, Deshmukh VR, et al. Endovascular reconstruction with the Neuroform stent as monotherapy for the treatment of uncoilable intradural pseudoaneurysms. Neurosurgery. 2006;59:291-300; discussion 291-300.

10. Masuo O, Terada T, Walker G, et al. Study of the patency of small arterial branches after stent placement with an experimental in vivo model. AJNR Am J Neuroradiol. 2002;23:706-710.

11. Kallmes DF, Ding YH, Dai D, et al. A new endoluminal, flow-disrupting device for treatment of saccular aneurysms. Stroke. 2007;38:2346-2352.

12. Sadasivan C, Cesar L, Seong J, et al. An original flow diversion device for the treatment of intracranial aneurysms: evaluation in the rabbit elastase-induced model. Stroke. 2009;40:952-958.

13. Byrne JV, Beltechi R, Yarnold JA, et al. Early experience in the treatment of intra-cranial aneurysms by endovascular flow diversion: a multicentre prospective study. PLoS One. 2010;5:e12492.

14. Brinjikji W, Lanzino G, Cloft HJ, et al. Platelet testing is associated with worse clinical outcomes for patients treated with the Pipeline embolization device. AJNR Am J Neuroradiol. 2015;36:2090-2095.

15. Walcott BP, Koch MJ, Stapleton CJ, Patel AB. Blood flow diversion as a primary treatment method for ruptured brain aneurysms—concerns, controversy, and future directions [published online November 14, 2016]. Neurocrit Care.

16. Lylyk P, Miranda C, Ceratto R, et al. Curative endovascular reconstruction of cerebral aneurysms with the pipeline embolization device: the Buenos Aires experience. Neurosurgery. 2009;64:632-642; discussion 642-643.

17. van Rooij WJ, Sluzewski M. Endovascular treatment of large and giant aneurysms. AJNR Am J Neuroradiol. 2009;30:12-18.

18. Cebral JR, Mut F, Raschi M, et al. Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatment. AJNR Am J Neuroradiol. 2011;32:27-33.

19. Kulcsár Z, Houdart E, Bonafé A, et al. Intra-aneurysmal thrombosis as a possible cause of delayed aneurysm rupture after flow-diversion treatment. AJNR Am J Neuroradiol. 2011;32:20-25.

20. Puffer RC, Kallmes DF, Cloft HJ, Lanzino G. Patency of the ophthalmic artery after flow diversion treatment of paraclinoid aneurysms. J Neurosurg. 2012;116:892-896.

21. Brinjikji W, Kallmes DF, Cloft HJ, Lanzino G. Patency of the anterior choroidal artery after flow-diversion treatment of internal carotid artery aneurysms. AJNR Am J Neuroradiol. 2015;36:537-541.

22. Chalouhi N, Daou B, Kung D, et al. Fate of the ophthalmic artery after treatment with the Pipeline embolization device. Neurosurgery. 2015;77:581-584; discussion 584.

23. Raz E, Shapiro M, Becske T, et al. Anterior choroidal artery patency and clinical follow-up after coverage with the Pipeline embolization device. AJNR Am J Neuroradiol. 2015;36:937-942.

24. Durst CR, Starke RM, Clopton D, et al. Endovascular treatment of ophthalmic artery aneurysms: ophthalmic artery patency following flow diversion versus coil embolization. J Neurointerv Surg. 2016;8:919-922.

25. Levitt MR, Park MS, Albuquerque FC, et al. Posterior inferior cerebellar artery patency after flow-diverting stent treatment. AJNR Am J Neuroradiol. 2016;37:487-489.

26. Szikora I, Berentei Z, Kulcsar Z, et al. Treatment of intracranial aneurysms by functional reconstruction of the parent artery: the Budapest experience with the pipeline embolization device. AJNR Am J Neuroradiol. 2010;31:1139-1147.

27. Becske T, Kallmes DF, Saatci I, et al. Pipeline for uncoilable or failed aneurysms: results from a multicenter clinical trial. Radiology. 2013;267:858-868.

28. Mohlenbruch MA, Herweh C, Jestaedt L, et al. The FRED flow-diverter stent for intracranial aneurysms: clinical study to assess safety and efficacy. AJNR Am J Neuroradiol. 2015;36:1155-1161.

29. Tanoue T, Tateshima S, Villablanca JP, et al. Wall shear stress distribution inside growing cerebral aneurysm. AJNR Am J Neuroradiol. 2011;32:1732-1737.

30. Xiang J, Damiano RJ, Lin N, et al. High-fidelity virtual stenting: modeling of flow diverter deployment for hemodynamic characterization of complex intracranial aneurysms. J Neurosurg. 2015;123:832-840.

31. Mascitelli JR, Moyle H, Oermann EK, et al. An update to the Raymond–Roy Occlusion Classification of intracranial aneurysms treated with coil embolization. J Neurointerv Surg. 2015;7:496-502.

32. Stapleton CJ, Torok CM, Rabinov JD, et al. Validation of the Modified Raymond–Roy classification for intracranial aneurysms treated with coil embolization. J Neurointerv Surg. 2016;8:927-933.

33. Raymond J, Guilbert F, Weill A, et al. Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke. 2003;34:1398-1403.

34. Roy D, Milot G, Raymond J. Endovascular treatment of unruptured aneurysms. Stroke. 2001;32:1998-2004.

35. Gruber A, Killer M, Bavinzski G, Richling B. Clinical and angiographic results of endosaccular coiling treatment of giant and very large intracranial aneurysms: a 7-year, single-center experience. Neurosurgery. 1999;45:793-803; discussion 803-794.

36. Spiotta AM, Gupta R, Fiorella D, et al. Mid-term results of endovascular coiling of wide-necked aneurysms using double stents in a Y configuration. Neurosurgery. 2011;69:421-429.

37. Pierot L, Cognard C, Spelle L, Moret J. Safety and efficacy of balloon remodeling technique during endovascular treatment of intracranial aneurysms: critical review of the literature. AJNR Am J Neuroradiol. 2012;33:12-15.

38. Hong Y, Wang YJ, Deng Z, et al. Stent-assisted coiling versus coiling in treatment of intracranial aneurysm: a systematic review and meta-analysis. PLoS One. 2014;9:e82311.

39. Chalouhi N, Tjoumakaris S, Starke RM, et al. Comparison of flow diversion and coiling in large unruptured intracranial saccular aneurysms. Stroke. 2013;44:2150-2154.

40. Raymond J, Gentric JC, Darsaut TE, et al. Flow diversion in the treatment of aneurysms: a randomized care trial and registry [published online November 4, 2016]. J Neurosurg.

41. Griessenauer CJ, Ogilvy CS, Foreman PM, et al. Pipeline embolization device for small intracranial aneurysms: evaluation of safety and efficacy in a multicenter cohort [published online August 1, 2016]. Neurosurgery.

42. Petr O, Brinjikji W, Cloft H, et al. Current trends and results of endovascular treatment of unruptured intracranial aneurysms at a single institution in the flow-diverter era. AJNR Am J Neuroradiol. 2016;37:1106-1113.

43. Lin N, Brouillard AM, Krishna C, et al. Use of coils in conjunction with the pipeline embolization device for treatment of intracranial aneurysms. Neurosurgery. 2015;76:142-149.

44. Gaberel T, Borha A, di Palma C, Emery E. Clipping versus coiling in the management of posterior communicating artery aneurysms with third nerve palsy: a systematic review and meta-analysis. World Neurosurg. 2016;87:498-506.e4.

45. Brown BL, Lopes D, Miller DA, et al. The fate of cranial neuropathy after flow diversion for carotid aneurysms. J Neurosurg. 2016;124:1107-1113.

46. Moon K, Albuquerque FC, Ducruet AF, et al. Resolution of cranial neuropathies following treatment of intracranial aneurysms with the Pipeline embolization device. J Neurosurg. 2014;121:1085-1092.

47. Lin N, Lanzino G, Lopes DK, et al. Treatment of distal anterior circulation aneurysms with the Pipeline embolization device: a US multicenter experience. Neurosurgery. 2016;79:14-22.

48. Clarençon F, Di Maria F, Gabrieli J, et al. Flow diverter stents for the treatment of anterior cerebral artery aneurysms: safety and effectiveness [published online August 7, 2015]. Clin Neuroradiol.

49. Chalouhi N, Zanaty M, Whiting A, et al. Safety and efficacy of the Pipeline embolization device in 100 small intracranial aneurysms. J Neurosurg. 2015;122:1498-1502.

50. Phillips TJ, Wenderoth JD, Phatouros CC, et al. Safety of the pipeline embolization device in treatment of posterior circulation aneurysms. AJNR Am J Neuroradiol. 2012;33:1225-1231.

51. Kulcsár Z, Ernemann U, Wetzel SG, et al. High-profile flow diverter (silk) implantation in the basilar artery: efficacy in the treatment of aneurysms and the role of the perforators. Stroke. 2010;41:1690-1696.

52. Siddiqui AH, Abla AA, Kan P, et al. Panacea or problem: flow diverters in the treatment of symptomatic large or giant fusiform vertebrobasilar aneurysms. J Neurosurg. 2012;116:1258-1266.

53. Fischer S, Vajda Z, Aguilar Perez M, et al. Pipeline embolization device (PED) for neurovascular reconstruction: initial experience in the treatment of 101 intracranial aneurysms and dissections. Neuroradiology. 2012;54:369-382.

54. Munich SA, Tan LA, Keigher KM, et al. The Pipeline embolization device for the treatment of posterior circulation fusiform aneurysms: lessons learned at a single institution. J Neurosurg. 2014;121:1077-1084.

55. Waldau B, Reavey-Cantwell JF, Lawson MF, et al. Intentional partial coiling dome protection of complex ruptured cerebral aneurysms prevents acute rebleeding and produces favorable clinical outcomes. Acta Neurochirurgica. 2012;154:27-31.

56. Chiu AH, Ramesh R, Wenderoth J, et al. Use of aspirin as sole oral antiplatelet therapy in acute flow diversion for ruptured dissecting aneurysms. BMJ Case Rep. 2016;2016:bcr2016012657.

57. Kung DK, Policeni BA, Capuano AW, et al. Risk of ventriculostomy-related hemorrhage in patients with acutely ruptured aneurysms treated using stent-assisted coiling. J Neurosurg. 2011;114:1021-1027.

58. Meling TR, Sorteberg A, Bakke SJ, et al. Blood blister-like aneurysms of the internal carotid artery trunk causing subarachnoid hemorrhage: treatment and outcome. J Neurosurg. 2008;108:662-671.

59. Gaughen JR Jr, Hasan D, Dumont AS, et al. The efficacy of endovascular stenting in the treatment of supraclinoid internal carotid artery blister aneurysms using a stent-in-stent technique. AJNR Am J Neuroradiol. 2010;31:1132-1138.

60. Kalani MY, Zabramski JM, Kim LJ, et al. Long-term follow-up of blister aneurysms of the internal carotid artery. Neurosurgery. 2013;73:1026-1033; discussion 1033.

61. Linfante I, Mayich M, Sonig A,et al. Flow diversion with Pipeline embolic device as treatment of subarachnoid hemorrhage secondary to blister aneurysms: dual-center experience and review of the literature [published online April 13, 2016]. J Neurointerv Surg.

62. Rouchaud A, Brinjikji W, Cloft HJ, Kallmes DF. Endovascular treatment of ruptured blister-like aneurysms: a systematic review and meta-analysis with focus on deconstructive versus reconstructive and flow-diverter treatments. Am J Neuroradiol. 2015;36:2331-2339.

63. Walcott BP, Stapleton CJ, Choudhri O, Patel AB. Flow diversion for the treatment of intracranial aneurysms. JAMA Neurol. 2016;73:1002-1008.

64. Adeeb N, Griessenauer CJ, Moore J, et al. Pipeline embolization device for recurrent cerebral aneurysms after microsurgical clipping. World Neurosurg. 2016;93:341-345.

65. Becske T, Potts MB, Shapiro M, et al. Pipeline for uncoilable or failed aneurysms: 3-year follow-up results. J Neurosurg. Oct 14 2016:1-8.

66. Nelson PK, Lylyk P, Szikora I, et al. The pipeline embolization device for the intracranial treatment of aneurysms trial. AJNR Am J Neuroradiol. 2011;32:34-40.

67. Rouchaud A, Brinjikji W, Lanzino G, et al. Delayed hemorrhagic complications after flow diversion for intracranial aneurysms: a literature overview. Neuroradiology. 2016;58:171-177.

68. Brinjikji W, Murad MH, Lanzino G, et al. Endovascular treatment of intracranial aneurysms with flow diverters: a meta-analysis. Stroke. 2013;44:442-447.

69. Kallmes DF, Hanel R, Lopes D, et al. International retrospective study of the pipeline embolization device: a multicenter aneurysm treatment study. AJNR Am J Neuroradiol. 2015;36:108-115.

70. Chiu AH, Wenderoth J. Cerebral hyperperfusion after flow diversion of large intracranial aneurysms. BMJ Case Rep. 2012;2012:bcr201201479.

Matthew J. Koch, MD
Neuroendovascular Fellow
Massachusetts General Hospital
Harvard Medical School
Boston, Massachusetts
Disclosures: None.

Christopher J. Stapleton, MD
Neuroendovascular Fellow
Massachusetts General Hospital
Harvard Medical School
Boston, Massachusetts
Disclosures: None.

Brian P. Walcott, MD
Attending Neurosurgeon
Massachusetts General Hospital
Instructor in Neurosurgery
Harvard Medical School
Boston, Massachusetts
Disclosures: None.

Scott B. Raymond, MD, PhD
Neuroendovascular Fellow
Massachusetts General Hospital
Harvard Medical School
Boston, Massachusetts
Disclosures: None.

Aman B. Patel, MD
Director of Cerebrovascular and Endovascular
Co-Director of the Neuroendovascular Program
Massachusetts General Hospital
Boston, Massachusetts
Disclosures: Consultant to Penumbra, Inc. and Medtronic.