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CLI Trial Update: The BEST-CLI Trial

A summary of the trial's design and goals and an update on its progress to date.

By Matthew Menard, MD; Alik Farber, MD; and Kenneth Rosenfield, MD

BEST-CLI Shows Lower Incidence of Major Adverse Limb Events or Death With Surgical Bypass Versus Endovascular Treatment in CLTI Patients With Adequate GSV

With Alik Farber, MD, MBA; Matthew Menard, MD; and Kenneth Rosenfield, MD, MHCDS

Considering the Next Horizon of CLTI Trials

With BEST-CLI and BASIL-2 now complete, physicians contemplate the next phase of CLTI trials, including areas of focus and predictions for the most clinically impactful data.

With Marianne Brodmann, MD; Kumar Madassery, MD, FSIR; Sabine Steiner, MD; Zola N’Dandu, MD, FSCAI; and Matthew Menard, MD

Surveying the CLI Landscape

By Jos C. van den Berg, MD, PhD, and Jihad A. Mustapha, MD

Leveling Up in Limb Preservation

By Jos C. van den Berg, MD, PhD

Creating CLI Teams

The VIVA Physicians' Vascular Leaders Forum offers guidance on core competencies and quality measures for establishing multidisciplinary CLI care teams.

By John H. Rundback, MD; Tony S. Das, MD; Peter A. Schneider, MD; and Michael R. Jaff, DO; on behalf of the VLF participants

BEST-CLI Trial Update at 1 Year of Enrollment

Principal Investigators Alik Farber, MD; Matthew T. Menard, MD; and Kenneth Rosenfield, MD, discuss the trial's progress and recent protocol modifications.

Behind the BEST-CLI Trial

Principal Investigators Alik Farber, MD; Matthew T. Menard, MD; and Kenneth Rosenfield, MD, discuss the structure and origins of this study comparing best endovascular and surgical options for critical limb ischemia.

Entry and Exit Strategies

By John H. Rundback, MD, FAHA, FSVM, FSIR

Surveying the Below-the-Knee Revascularization Trial Landscape

Trialists discuss lessons learned from key CLI/CLTI trials, including BEST-CLI, BASIL-2, LIFE-BTK, and SAVAL.

With Brian DeRubertis, MD; Alik Farber, MD, MBA, FACS, DFSVS; Patrick Geraghty, MD, RPVI, DFSVS; and Athanasios Saratzis, MBBS, FHEA, PhD, FRCS

EVAR Versus the Endoleak

Understanding the risks for developing type I, II, and III endoleaks and the available treatment options when they are identified.

By Matthew J. Eagleton, MD